NFL Games This Weekend: TV schedule, predictions, matchups & betting insights
NFL games this weekend
NFL Games This Weekend: As we roll into Week 3 of the NFL season, there are a number of intriguing matchups, potential upset scenarios, and storylines that could swing lines. Week 3 of the NFL season kicks off this weekend, and fans are in for a loaded slate of games from Friday, September 19 through Sunday, September 21, 2025. While Thursday Night Football set the tone earlier in the week, the spotlight now shifts to Sunday, where several high-stakes clashes headline the schedule. Bettors and fans alike will have their eyes on the Giants visiting the Kansas City Chiefs in primetime and the Ravens squaring off against the Lions on Monday night to close out the week.
For those tracking betting angles, this weekend offers a mix of powerhouse showdowns, potential upsets, and opportunities in props and live lines. From Patrick Mahomes trying to steady Kansas City after a shaky start to the Ravens defense testing one of the league’s most exciting offenses, the stage is set for a weekend that could reshape early-season narratives. Whether you’re watching for the drama on the field or studying the odds board, here’s the complete TV schedule, key matchups, odds outlook, and the star players who could swing results.
Here’s what bettors need to know for Sept. 19-21.
NFL Games This Weekend TV Schedule & Key Game Times
Date
Time (ET)
Matchup
Network / Platform
Saturday, Sept 20
—
No regular season games scheduled
—
Sunday, Sept 21
1:00 PM
Multiple early games across the league
CBS / FOX (regional; stream via NFL+ etc.)
4:05 PM
Late afternoon games (second wave)
CBS / FOX
8:20 PM
New York Giants vs. Kansas City Chiefs
NBC (Sunday Night Football)
Monday, Sept 22
8:15 PM
Baltimore Ravens vs Detroit Lions
ESPN / ABC (Monday Night Football)
Note: Exact kickoff times for all games are subject to regional broadcasts and scheduling shifts. Streams and alternate platforms (NFL+, Peacock, Prime Video, etc.) may carry some games depending on market.
NFL Games This Weekend: Full Schedule
Thursday, September 18, 2025
Buffalo Bills at Miami Dolphins
Sunday, September 21, 2025 (Early Slate – 1 PM ET)
Atlanta Falcons at Carolina Panthers
Green Bay Packers at Cleveland Browns
Houston Texans at Jacksonville Jaguars
Cincinnati Bengals at Minnesota Vikings
Pittsburgh Steelers at New England Patriots
Los Angeles Rams at Philadelphia Eagles
New York Jets at Tampa Bay Buccaneers
Indianapolis Colts at Tennessee Titans
Las Vegas Raiders at Washington Commanders
Sunday, September 21, 2025 (Late Slate – 4:05/4:25 PM ET)
Denver Broncos at Los Angeles Chargers
New Orleans Saints at Seattle Seahawks
Dallas Cowboys at Chicago Bears
Arizona Cardinals at San Francisco 49ers
Sunday Night Football, September 21, 2025 (8:20 PM ET)
New York Giants at Kansas City Chiefs
Monday Night Football, September 22, 2025 (8:15 PM ET)
Baltimore Ravens at Detroit Lions
NFL Games This Weekend: Key Matchups & What’s On the Line
Here are the headline games and storylines to watch.
Giants vs. Chiefs (Sunday Night Football)
Why it matters: The Chiefs begin the season 0-2, and media attention has amplified with high expectations. A win against the Giants could quiet doubts about whether they can still contend. The Giants, meanwhile, need consistency to build momentum.
Betting angle: Expect Kansas City to be favorites, but given pressure and recent performance, there could be value in the Giants with points. The total might trend toward “over” if both teams feel urgency to score.
Players to watch: Patrick Mahomes (KC) in prime time always draws eyes. On the Giants side, their offense’s ability to respond under pressure will be critical.
Why it matters: Ravens typically bring a tough defensive scheme. Lions are rising as a high-powered offense. Matchups like this test whether the Lions can break through when defenses are disciplined.
Betting angle: Because of Ravens’ defensive strength, may be attractive to lean toward them if the spread is narrow. Or, consider props on big plays by Lions if their passing game can stretch the field. Total points might be more volatile in the second half.
NFL Games This Weekend: Odds & Predictions Snapshot
Here are some early look predictions and betting lines (spreads / totals / moneylines) for some of the Sunday matchups. These are approximate and will vary by sportsbook / region, but helpful for framing expectations.
* Estimates as per recent lines; subject to movement.
NFL Games This Weekend: Big Names On Deck
Patrick Mahomes — always a focal point, particularly in primetime with eyes on how his team rebounds.
Lions’ Offensive Weapons — if their offense is clicking, they could challenge Ravens in matchup and props.
Defensive Stars — Ravens’ front, pass rushes around the league; turnovers always matter in swing games.
Giants’ Resilience — How well they handle pressure will determine whether the Chiefs’ offense flows or gets disrupted.
NFL Games This Weekend: Betting Tips & Things to Watch
Line movement: Keep tabs on injury reports late in the week, especially for key QBs and offensive line. Those tend to shift spreads.
Weather & venue effects: Although most games are in standard conditions, any outdoor games with potential for weather (wind, rain) could influence totals or game flow.
Prop bets & player stats: Props on completions, passing yards, RB rushing yardage tend to be solid value. Also defensive props like sacks or turnovers in games involving teams known for high-pressure defenses.
Live betting: Some games will open up in live betting — e.g. if a favorite jumps early or is slow out of the gate, lines for second half/spread/over might swing. Be ready to strike if you have info or see momentum.
Predictions for this week NFL games
Best Bet: Chiefs bounce back, win at home vs. Giants by ~14.
Sleeper Upset Alert: If Giants’ defense steps up early, maybe they make it competitive; but pulling off full upset seems long odds.
Total Game Pick: Chiefs vs. Giants may go over, especially if both QBs push tempo. Ravens vs. Lions might stay near the total or slightly under if the defenses dominate.