The NFL’s schedule Week 2 is packed with betting angles, from a Thursday night NFC clash to a Sunday afternoon Super Bowl rematch. Kansas City hosts Philadelphia in the headline 4 p.m. EST game, as Patrick Mahomes and the Chiefs look to bounce back from a Week 1 loss. The action kicks off Thursday when the Washington Commanders face the Green Bay Packers, both fresh off division wins.
Week 2 NFL Schedule: Chiefs and other contenders chasing first win
Several top contenders enter Week 2 searching for their first victory of the 2025 season. The Chiefs, Detroit Lions, and Baltimore Ravens all dropped their openers, raising the stakes for this week’s lines. Bettors should watch how these teams respond under pressure.
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Surprise winners shift betting value
Week 1 delivered its usual dose of upsets, with the Los Angeles Chargers and Las Vegas Raiders posting standout wins. Both now return for Monday Night Football in Week 2, giving bettors another shot at value in what could be a tight matchup.
Where to watch Week 2 NFL action
Fans in the United States can catch the games live on ESPN, CBS, FOX, and NBC, while Monday Night Football will air on ESPN/ABC. For streaming, NFL+ and ESPN+ are the go-to options, and international viewers can follow along on the NFL Game Pass International service.
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NFL Week 2: Key matchups to bet on
- Chiefs vs. Eagles (Sunday, 4 p.m. EST): A rematch of Super Bowl LVII and the clear headline game of the week. Both teams are playoff favorites, and the spread could move quickly.
- Commanders vs. Packers (Thursday night): Both picked up division wins in Week 1, making this a key test for bettors looking at early-season form.
- Chargers vs. Raiders (Monday night): After Week 1 upsets, both sides come in with momentum, and this could turn into one of the tighter betting lines of Week 2.
- Giants vs. Cowboys (Sunday, 1 p.m. EST): A classic NFC East rivalry, with Dallas usually attracting heavy betting action.
Week 2 NFL: Players to watch for betting props
- Patrick Mahomes (Chiefs): Coming off a Week 1 loss, Mahomes is a popular play in passing yards and touchdown markets.
- Jalen Hurts (Eagles): Always a dual-threat option, Hurts’ rushing props and anytime touchdown scorer lines are worth a look.
- Jordan Love (Packers): After a solid opener, Love faces a prime-time test against Washington’s defense.
- Justin Herbert (Chargers): Fresh off a big win, Herbert’s passing yard props could draw attention in a shootout with the Raiders.
- Davante Adams (Raiders): A go-to target for Las Vegas, Adams is a top option in receiving yard and anytime TD markets.
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NFL Schedule Week 2 and betting slate
Here’s how the Week 2 matchups line up (odds via DraftKings Sportsbook):
Thursday Night Football – Sept. 11
- Washington Commanders vs. Green Bay Packers
Sunday, Sept. 14 – 1 p.m. EST Games
- New York Giants vs. Dallas Cowboys
- Los Angeles Rams vs. Tennessee Titans
- Jacksonville Jaguars vs. Cincinnati Bengals
- Cleveland Browns vs. Baltimore Ravens
- Buffalo Bills vs. New York Jets
- New England Patriots vs. Miami Dolphins
- San Francisco 49ers vs. New Orleans Saints
- Chicago Bears vs. Detroit Lions
- Seattle Seahawks vs. Pittsburgh Steelers
Sunday, Sept. 14 – 4 p.m. EST Games
- Denver Broncos vs. Indianapolis Colts
- Carolina Panthers vs. Arizona Cardinals
- Philadelphia Eagles vs. Kansas City Chiefs
Sunday Night Football – Sept. 14
- Atlanta Falcons vs. Minnesota Vikings
Monday Night Football – Sept. 15
- Tampa Bay Buccaneers vs. Houston Texans
- Los Angeles Chargers vs. Las Vegas Raiders
Betting outlook for Week 2 NFL
With a mix of division games, bounce-back spots, and prime-time showcases, Week 2 offers plenty of betting opportunities. Early lines could move quickly, especially around the Chiefs-Eagles and Chargers-Raiders matchups. Bettors tracking player props, anytime touchdown markets, and spreads may find strong value before the weekend action kicks off.
