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NFL Week 4 betting preview: Odds, picks, and predictions for every game

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Week 3 of the NFL season was pure chaos for bettors. For the first time in league history, we saw multiple interceptions, blocked field goals, and punt returns for touchdowns all in the same day. Double-digit leads vanished in minutes, spreads flipped late, and several “safe” favorites collapsed in the fourth quarter. The Rams gave up a 19-point cushion to the Eagles and lost the cover on a blocked field goal return. The Buccaneers almost blew a 17-point lead to the Jets before sneaking out a win. Meanwhile, the Packers and Broncos also surrendered late leads, costing backers in painful fashion.

As we move into Week 4, the board is loaded with intrigue — starting with Thursday’s Seattle win over Arizona and capped by the Packers-Cowboys “Micah Parsons revenge game” on Sunday night. With the first-ever NFL game in Ireland and plenty of playoff-caliber matchups, this slate is packed with betting opportunities. Let’s break down the key games, using the latest odds from FanDuel Sportsbook.

Seattle Seahawks (-1.5) at Arizona Cardinals (Final: Seahawks 23, Cardinals 20)

Seattle extended its dominance over Arizona to eight straight wins, covering yet again. The Cardinals continue to struggle without James Conner, and their offense lacks explosiveness. Bettors who grabbed Seattle early cashed with little sweat.

Minnesota Vikings (-2.5) vs Pittsburgh Steelers (Ireland)

Dajani: Vikings -2.5. Minnesota thrives overseas (4-0 all-time in international games) and Carson Wentz has sparked life into the offense. Prediction: Vikings 16, Steelers 12.
Taranto: Steelers +2.5. The Vikings’ defense won’t keep replicating touchdowns, and Pittsburgh is steadier than Cincinnati. Prediction: Steelers 24, Vikings 10.

Betting angle: The neutral site evens things, but the Vikings’ international track record is notable.

Philadelphia Eagles (-3.5) at Tampa Bay Buccaneers

Dajani: Eagles -3.5. Tampa is banged up with injuries to the O-line and Mike Evans out. Prediction: Eagles 27, Bucs 23.
Taranto: Buccaneers +3.5. History favors Tampa at home, where they’ve beaten Philly in multiple big spots. Prediction: Bucs 28, Eagles 16.

Betting angle: Tampa has been Philly’s kryptonite, but Hurts’ squad has more firepower if A.J. Brown gets going.

Indianapolis Colts at Los Angeles Rams (-3.5)

Dajani: Rams -3.5. Stat trend: 3-0 underdogs vs non-3-0 teams are 1-10 ATS since 2014. Prediction: Rams 30, Colts 24.
Taranto: Colts +3.5. Indy has momentum and a healthier QB situation. Prediction: Colts 24, Rams 17.

Betting angle: Rams have talent edge, but Colts’ ATS run (3-0) keeps them in play.

Baltimore Ravens (-2.5) at Kansas City Chiefs

Dajani: Chiefs +2.5. Patrick Mahomes thrives as an underdog (12-3-1 ATS career). Prediction: Chiefs 26, Ravens 23.
Taranto: Ravens -2.5. Baltimore’s offense has been consistent at 30+ points per game. Prediction: Ravens 27, Chiefs 20.

Betting angle: This is Mahomes vs Lamar again — history leans Chiefs, current form leans Ravens.

Green Bay Packers (-6.5) at Dallas Cowboys (SNF)

Dajani: Packers -6.5. Dallas’ defense ranks bottom six, and CeeDee Lamb is sidelined. Prediction: Packers 27, Cowboys 17.
Taranto: Packers -6.5. No Parsons, no Lamb, no chance. Prediction: Packers 41, Cowboys 13.

Betting angle: Both experts agree: Packers should roll.

New York Jets at Miami Dolphins (-2.5) (MNF)

Dajani: Dolphins -2.5. Extra rest after TNF is key. Prediction: Dolphins 17, Jets 13.
Taranto: Jets +2.5. Jets are scrappy and due to finish strong. Prediction: Jets 23, Dolphins 10.

Betting angle: Miami’s speed vs Jets’ grind-it-out style — a classic clash of game scripts.

Cincinnati Bengals at Denver Broncos (-7.5) (MNF)

Dajani: Broncos -7.5. Denver needs a bounce-back, and Bo Nix historically responds after losses. Prediction: Broncos 30, Bengals 20.
Taranto: Broncos -7.5. Denver’s altitude and strong roster should overwhelm. Prediction: Broncos 34, Bengals 17.

Betting angle: Both lean Broncos, making Denver the sharp side against a reeling Bengals team.

Betting takeaway for Week 4

Week 3 reminded everyone that no lead is safe and no spread is guaranteed. Bettors should tread carefully, especially with road favorites and teams missing key playmakers. Look for value in injury mismatches (Packers vs Cowboys) and situational angles (Vikings’ history abroad, Dolphins’ mini-bye).