NFL Week 5 predictions and betting picks: Rams, Vikings, Bills and Chiefs headline key games

NFL Week 5 predictions

NFL Week 5 is loaded with matchups that matter for both standings and bettors. From the NFC West clash between the San Francisco 49ers and Los Angeles Rams on Thursday Night Football to the international game in London, and prime-time battles featuring the Patriots, Bills, Chiefs, and Jaguars, this week’s slate offers plenty of action. Bettors will be watching closely as teams fight to keep pace early in the season.

Thursday Night Football: 49ers at Rams

Game time: Oct. 2, 5:15 p.m. MST, Prime Video
The NFC West race gets real with the 49ers visiting the Rams. Both sides are 3-1, and the winner grabs an early divisional edge. Los Angeles’ defense has the tools to slow down San Francisco’s attack, and home-field advantage could make the difference.

Pick: Rams 27, 49ers 24

London spotlight: Vikings vs Browns

Game time: Oct. 5, 6:30 a.m. MST, NFL Network
Minnesota heads to London after a rough Week 4 loss, while Cleveland continues to search for consistency. The Vikings’ passing game led by Justin Jefferson should shine overseas.

Pick: Vikings 24, Browns 14

Sunday early slate

Texans at Ravens, 10 a.m. CBS
Both teams sit at 1-3, and neither can afford another loss. Baltimore should grind out a close win at home.
Pick: Ravens 23, Texans 20

Dolphins at Panthers, 10 a.m. FOX
Carolina is unbeaten at home, while Miami has struggled to finish games. Expect Bryce Young to deliver late.
Pick: Panthers 24, Dolphins 23

Raiders at Colts, 10 a.m. FOX
Tough luck for both in Week 4, but Indy has the edge with home support.
Pick: Colts 27, Raiders 20

Giants at Saints, 10 a.m. CBS
The Giants are trending up after a strong win. The Saints remain winless.
Pick: Giants 28, Saints 20

Cowboys at Jets, 10 a.m. FOX
Dallas is scoring big despite inconsistency. The Jets can’t keep up.
Pick: Cowboys 31, Jets 20

Broncos at Eagles, 10 a.m. CBS
Philly thrives at home, while Denver faces travel on short rest.
Pick: Eagles 27, Broncos 19

Sunday late slate

Titans at Cardinals, 1:05 p.m. CBS
Tennessee’s offense is sputtering. Arizona gets back on track.
Pick: Cardinals 24, Titans 13

Buccaneers at Seahawks, 1:05 p.m. CBS
Both are 3-1, but Seattle is rested and confident.
Pick: Seahawks 23, Buccaneers 20

Lions at Bengals, 1:25 p.m. FOX
Detroit’s offense is rolling, while Cincinnati struggles to keep up.
Pick: Lions 30, Bengals 17

Commanders at Chargers, 1:25 p.m. FOX
This could be tight, but Justin Herbert makes the difference.
Pick: Chargers 27, Commanders 24

Sunday Night Football: Patriots at Bills

Game time: Oct. 5, 5:20 p.m. MST, NBC
New England may keep things close early, but Buffalo’s Josh Allen leads an explosive attack at home.

Pick: Bills 34, Patriots 20

Monday Night Football: Chiefs at Jaguars

Game time: Oct. 6, 5:15 p.m. MST, ESPN/ABC
Kansas City is hot after back-to-back wins, and Patrick Mahomes looks sharp again. Jacksonville keeps it competitive but falls short.

Pick: Chiefs 24, Jaguars 23