Week 6 college football betting preview: Key odds, spreads and picks

Week 6 of college football brings a mixed slate for bettors as nearly half the SEC takes a break, leaving fewer options in one of the most popular betting conferences. But the action is far from thin. Alabama takes on Vanderbilt, Texas travels to Florida, and Miami faces Florida State in one of the sport’s fiercest rivalries. Add Clemson’s return from a bye against North Carolina, plus several top-10 teams trying to stay perfect, and there are plenty of spreads, totals, and money-line plays drawing attention on betting sites. With major storylines across both the SEC and ACC, this week’s lines are already shifting as bettors look for value.

Miami vs. Florida State highlights ACC rivalry week

One of the weekend’s headline games features No. 3 Miami against No. 18 Florida State. Oddsmakers have Miami favored at -4.5, and early money has leaned toward the Hurricanes. Rivalry games, however, often play out closer than expected, which makes the spread worth watching.

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Clemson vs. UNC: Star coaches in focus

Clemson returns from its bye to meet North Carolina, with the Tigers listed as 14-point favorites. This game also marks the first sideline meeting between Bill Belichick and Dabo Swinney, adding intrigue beyond the field. Clemson is yet to cover this season, raising questions about whether they can break the trend here.

Louisville favoured over Texas

For Week 6, two games would be particularly in interest:

• Louisville (-6.5) vs. Virginia: Louisville has won seven straight, while Virginia has struggled with turnovers and road games.
• Texas (-4.5) vs. Florida: Arch Manning has been in strong form, while Florida has one of the SEC’s weakest scoring offenses.

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Other notable Week 6 odds

• Kentucky vs. Georgia (-20.5, 48.5)
• Wisconsin vs. Michigan (-17.5, 43.5)
• Air Force vs. Navy (-12.5, 51.5)
• Boise State vs. Notre Dame (-20.5, 62.5)
• Minnesota vs. Ohio State (-23.5, 43.5)

The model also projects multiple underdogs to win outright in Week 6. That could bring strong value for money-line bettors. With several heavy favorites across the slate, sharp bettors may find opportunities in live markets and totals as lines shift.

FAQs

Q1. What is the biggest rivalry game in Week 6 of college football?
Miami vs. Florida State is the marquee rivalry, with the Hurricanes favored by 4.5 points over the Seminoles.

Q2. Which SEC game has strong betting interest?
Texas vs. Florida is one of the most talked-about SEC matchups, with Texas listed at -4.5 on the spread.

Q3. Which team is the betting model most confident in for Week 6?
Louisville (-6.5) against Virginia is highlighted as one of the strongest spread plays by SportsLine’s model.

Q4. Are there any heavy favorites this week?
Yes. Teams like Georgia (-20.5), Michigan (-17.5), and Ohio State (-23.5) are all double-digit favorites.

Q5. Where can I find more betting predictions for Week 6?
You can get the full list of computer model picks and simulations on SportsLine.